The Screening, Brief Intervention, and Referral to Treatment (SBIRT) model has been shown to be an effective approach for the identification and intervention for hazardous substance use, misuse, and substance use disorders (SUD) and for reducing the potential for psychosocial and/or health problems (Babor et al., 2007). However, application of the model for use among transgender and nonbinary (TNB) populations has yet to be fully understood and requires additional research. Our goal is to provide practice guidance for the utilization of the SBIRT model with TNB populations.